As such, epidermal biological and physical characteristics play an enormous role in resistance to environmental stressors such as infectious pathogens, chemical agents and UV. The epidermis, of ectodermal origin, is the outermost layer and serves as the body’s point of contact with the environment. Skin is organized into two primary layers, epidermis and dermis, which together are made up of epithelial, mesenchymal, glandular and neurovascular components. We are interested in developing UV-protective approaches based on a detailed understanding of molecular events that occur after UV exposure, focusing particularly on epidermal melanization and the role of the MC1R in genome maintenance.Ĭomprising roughly 16% of body mass, the skin is the largest organ of the body. Polymorphisms of the melanocortin 1 receptor ( MC1R) gene, in particular, correlate with fairness of skin, UV sensitivity, and enhanced cancer risk. Genetic factors also influence risk of UV-mediated skin disease. UV is epidemiologically and molecularly linked to the three most common types of skin cancer, basal cell carcinoma, squamous cell carcinoma and malignant melanoma, which together affect more than a million Americans annually. Nonetheless, excessive exposure to UV carries profound health risks, including atrophy, pigmentary changes, wrinkling and malignancy. However, UV also benefits human health by mediating natural synthesis of vitamin D and endorphins in the skin, therefore UV has complex and mixed effects on human health. In environmental abundance, UV is the most important modifiable risk factor for skin cancer and many other environmentally-influenced skin disorders. That product will add Victoria 4 UVs to the Genesis 2 Female base, only then was I able to use the converted Victoria 4 textures on my new Genesis 2 Ursila character.UV radiation (UV) is classified as a “complete carcinogen” because it is both a mutagen and a non-specific damaging agent and has properties of both a tumor initiator and a tumor promoter. So that meant having to convert Victoria 3 textures, and the only product I have to do texture conversions is Texture Convertor 2 (TC2) Bundle, and that product will only convert from Victoria 3 to Victoria 4.Īfter converting the Victoria 3 textures to Victoria 4 I then needed to use another product to help me out, Victoria 4 for Genesis 2 Female. This, as it turned out, was not going to work because Genesis Generation X2 does not convert Victoria 3 meshes to Genesis 3 Female, only up-to Genesis 2 Female.Ĭayman Studios does not have a “Legacy UVs for Genesis 2: Special Edition – Victoria 3” product. I even purchased the Legacy UVs for Genesis 3: Special Edition – Victoria 3 product so that I could just use the Victoria 3 textures on the Genesis 3 Female base. Initially I wanted to convert Ursila from Victoria 3 to the Genesis 3 Female base. I converted Ursila for V3, an alien character, to the Genesis 2 Female base.
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